Effect of tretinoin on fibroblasts

Therefore,Effect of tretinoin on fibroblasts Articles in recent years, many researchers use the fibroblast cell culture techniques to clarify the scar formation and regulation mechanism of scar formation. They have a study in fibroblast proliferation, collagen synthesis, cell activity and its influencing factors in controlled conditions. Tretinoin is a vitamin A-related drug with a wide range of pharmacological effects. The cosmetic raw material suppliers have received a clinical effect in the treatment of scars.

Scar formation is the result of wound healing. The pros and cons of wound healing is mainly depends on: the epithelial cell regeneration, migration and coverage; into the amount of fibroblast collagen synthesis, deposition and cross-linking. Fibroblasts can be divided into synthetic and contractile phenotype. In recent years: scar contracture tendency as a result of the contraction by fibroblasts. Therefore, if a certain drug is used in the process of wound healing, both to promote epithelial cell proliferation and differentiation, but also appropriate inhibition of fibroblast proliferation and activity will promote wound healing and prevent scar formation and contracture.

Fibroblast collagen synthesis in the cells and enhance the ability of fibroblasts to synthesize and secrete collagen or fibroblasts proliferation, may lead to the increase of the total amount of collagen. Is not difficult to imagine as fibroblast proliferation will inevitably lead to excessive production of collagen, if blocking the growth and proliferation of fibroblasts, it will prevent occurrence and development of scars.

A large number of cytological and biochemical studies have shown that collagen synthesis in fibroblasts in the rough endoplasmic reticulum, rough endoplasmic reticulum from the endoplasmic reticulum and ribosome formation of a complex functional units, cells for the biosynthesis of important bases. Has been confirmed into the rough surface of the fiber cells within the ER ribosome is the synthesis of collagen precursors place, and prove that this synthesis is not in a single ribosome, but in poly-ribosome. Therefore, attached to the ribosome on the endoplasmic reticulum, loss, and structural changes of the endoplasmic reticulum, of great significance for the synthesis of collagen. Tretinoin Buy

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